We first considered factors that modulate aggregation and subcellular distribution of LINE-1 ORF1p, including nuclear localization. In this study we explore these features and consider possible links between L1 expression and ALS. Certain features of the LINE-1 (L1) retrotransposon-encoded ORF1 protein (ORF1p) are analogous to those of neurodegeneration-associated RNA-binding proteins, including formation of cytoplasmic aggregates. Several studies have drawn connections between altered retrotransposon expression and ALS. 9 MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Western General Hospital, Edinburgh, UK.Īmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving loss of motor neurons and having no known cure and uncertain etiology.8 8Department of Human Genetics, Medical Faculty, University of Saarland, Homburg/Saar, Germany.7 7Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada, Spain.6 6Neuromuscular Division, Johns Hopkins University School of Medicine, Baltimore, Maryland USA.5 5Department of Neurosciences, School of Medicine, University of California at San Diego, San Diego, California USA.4 4School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.3 3Oncology Center-Cancer Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland USA.Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Granada, Spain. 1 1McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland USA.John is a wise and wonderful member of the HOF Volunteer Family. The next time John stops by the Visitor’s Center, or you see him walking by with his wife take a moment to say hello. One of John’s great personal interests is flying… John is a licensed pilot and flies his plane out of Summit Airport, and furthermore, is still involved in the Civil Air Patrol! It is evident when you talk to him that next to his family his community is a major focus of his life. John truly cares about this community and the future of Odessa. He is trained as a HOF docent and receptionist and is always willing to fill in a pinch. in Middletown… just to name a few.Īs Chairman of the Historic Odessa Foundation Advisory Committee, John has been instrumental in the formation of the Foundation as a volunteer organization.
John has been actively involved in many community organizations…holding offices in most of them the Appoquinimink School Board and the Church Connection Community U.M. He is a member and was past president of the Brain Injury Association of Delaware. He is active in Rotary International in the Middletown-Odessa Chapter, and was a member of the New Castle County Chamber of Commerce. He is a Mason, and since 1953 has served in various capacities, at all levels of membership, and in multiple chapters of that organization. John retired from PNC in 1992 as a Vice President. Twenty-seven of those years with the bank were spent in the Trust Department and nine years in Communications and Public Affairs. Army Field Medical Service Corps from 1953 to 1955, stationed at Brooke Army Medical Center in San Antonio, Texas.Īs a civilian, John was employed for the next thirty-six years by Equitable Security Trust Company, which later became Bank of Delaware, and finally became PNC. John was born in Vineland, New Jersey where he graduated from High School and then went on to Dickinson College in Carlisle, Pennsylvania. Their dedication to their community and their belief in support and good stewardship runs deep…their daughter Kelley also works as an HOF Volunteer, and their daughter-in-law, Rosemary, serves on the Historic Odessa Foundation Advisory Committee. They have three children and 4 grandchildren.
The young Goodier’s began their life together living in Bellevue Manor, eventually moving to Shallcross Lake in Middletown, and finally into Margie’s home town of Odessa in 1995. John’s mother was a Jefferis and it was one of her ancestors that married David Wilson of Cantwell’s Bridge in 1808. However, as John eventually came to find out, his connection to Odessa really began in the early nineteenth century. John is currently Chairman of the Historic Odessa Foundation Advisory Committee. John Goodier was first introduced to Odessa when he married Marjorie Loven in November of 1963. John claims that when he met Margie, he knew instantly he was going to marry her.
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